# README file

## General information

Data Set Title: "Synthetic cohort data generated from proximal femur statistical anatomy atlas".

Data Set Author/s: Antonino Amedeo La Mattina (Alma Mater Studiorum - University of Bologna; IRCCS Istituto Ortopedico Rizzoli), ORCID 0000-0002-9927-2393.

Data Set Contributor/s: Marco Viceconti (Alma Mater Studiorum - University of Bologna; IRCCS Istituto Ortopedico Rizzoli), ORCID 0000-0002-2293-1530.

Data Set Contact Person/s: Antonino Amedeo La Mattina (Alma Mater Studiorum - University of Bologna; IRCCS Istituto Ortopedico Rizzoli), ORCID 0000-0002-9927-2393, antonino.lamattina@unibo.it.

Data Set License: This data set is distributed under a Creative Commons Attribution-Non Commercial-Share Alike 4.0 International (CC BY-NC-SA 4.0) license, https://creativecommons.org/licenses/by-nc-sa/4.0/.

Publication Year: 2022

Project Info: CompBioMed2 (A Centre of Excellence in Computational Biomedicine), funded by European Commission, Horizon 2020 Programme. Grant Agreement num. 823712; https://www.compbiomed.eu/. In Silico World (Lowering barriers to ubiquitous adoption of In Silico Trials), funded by European Commission, Horizon 2020 Programme. Grant Agreement num. 101016503; https://insilico.world/.



## Data set Contents

The data set consists of
  - 1 compressed zip archive: "VirtualCohortDataset.zip"
  - 1 README file: "VirtualCohortDataset_README.txt"



## Data set documentation

### Abstract

This dataset contains data and results of a virtual cohort of proximal femurs generated with a PCA-based statistical anatomy atlas informed with 94 patients of the Sheffield cohort. Principal components were sampled using the empirical inverse cumulative distributions, creating 1044 synthetic patients. For each of the synthetic patients the Absolute Risk of Fracture at time 0 (ARF0) was estimated.

In the "VirtualCohortDataset.zip" compressed archive you will find the following files:
  - "CohortData.csv" contains patient total hip ("TotHip_aBMD" column) and femur neck (Neck_aBMD) bone mineral densities (both in g/cm2), height (in cm), weight (in kg), and estimated ARF0 (in percentage). Semicolon is used as field separator.
  - "CohortPCCoords.csv" contains the principal component coordinates used for each patient. Semicolon is used as field separator.
  - "TemplateMesh.cdb" contains the a FE model in ANSYS mesh archive format (point coordinates are in mm, Young moduli in MPa), generated with all the principal component coordinates equal to their distribution median value.