Abstract

The dataset contains data about metformin, levocetirizine and venlafaxine (and its main metabolite O-desmethyl venlafaxine) quantification in milk and blood collected from lactating sows and in piglets’ blood, obtained in the framework of the Horizon 2020 IMI funded project ConcePTION (grant agreement 821520). The main goal of ConcePTION is to establish a trusted ecosystem that can efficiently, systematically, and in an ethically responsible manner, generate and disseminate reliable evidence-based information regarding effects of medications used during pregnancy and breastfeeding to women and their healthcare providers. This will be achieved by generating, cataloguing, linking, collecting and analysing data from pharmacovigilance, modelling, routine healthcare, breastmilk samples through a large network. Task 3.3 of WP3 aims at developing and characterising a relevant in vivo model for drug passage from maternal blood to human breast milk. Based on a preliminary scan of existing literature, the chosen species to perform such non-clinical trial was the porcine one due to high anatomical and physiological similarities. After performing a pilot study using amoxicillin, 3 additional in vivo trials were scheduled using metofmin, levocetirizine and velnfaxine. The chosen medicines were in agreement with other tasks and work packages within the project.