ConcePTION WP3 task 3.3. Quantification of metformin, levocetirizine and venlafaxine/O-desmethyl venlafaxine in milk and blood collected from lactating sows and in piglets’ blood.

Ventrella, Domenico ; Bacci, Maria Laura ; Forni, Monica ; Elmi, Alberto (2023) ConcePTION WP3 task 3.3. Quantification of metformin, levocetirizine and venlafaxine/O-desmethyl venlafaxine in milk and blood collected from lactating sows and in piglets’ blood. University of Bologna. DOI 10.6092/unibo/amsacta/7430. [Dataset]
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Abstract

The dataset contains data about metformin, levocetirizine and venlafaxine (and its main metabolite O-desmethyl venlafaxine) quantification in milk and blood collected from lactating sows and in piglets’ blood, obtained in the framework of the Horizon 2020 IMI funded project ConcePTION (grant agreement 821520). The main goal of ConcePTION is to establish a trusted ecosystem that can efficiently, systematically, and in an ethically responsible manner, generate and disseminate reliable evidence-based information regarding effects of medications used during pregnancy and breastfeeding to women and their healthcare providers. This will be achieved by generating, cataloguing, linking, collecting and analysing data from pharmacovigilance, modelling, routine healthcare, breastmilk samples through a large network. Task 3.3 of WP3 aims at developing and characterising a relevant in vivo model for drug passage from maternal blood to human breast milk. Based on a preliminary scan of existing literature, the chosen species to perform such non-clinical trial was the porcine one due to high anatomical and physiological similarities. After performing a pilot study using amoxicillin, 3 additional in vivo trials were scheduled using metofmin, levocetirizine and velnfaxine. The chosen medicines were in agreement with other tasks and work packages within the project.

Abstract
Document type
Dataset
Creators
CreatorsAffiliationORCID
Ventrella, DomenicoDepartment of Veterinary Medical Sciences, Alma Mater Studiorum University of Bologna0000-0002-9330-979X
Bacci, Maria LauraDepartment of Veterinary Medical Sciences, Alma Mater Studiorum University of Bologna0000-0001-6702-5868
Forni, MonicaDepartment of Veterinary Medical Sciences, Alma Mater Studiorum University of Bologna0000-0003-1310-6202
Elmi, AlbertoDepartment of Veterinary Medical Sciences, Alma Mater Studiorum University of Bologna0000-0002-7827-5034
Subjects
DOI
Contributors
Name
Affiliation
Type
DeLise, Anthony
Novartis International AG
Researcher
Ashkenazi, Nurit
Teva Pharmaceutical Industries Ltd.
Researcher
Jacobsen, Kirsten
Ellegaard Gottingen Minipigs A/S
Researcher
Hansen, Mie Johanne
Ellegaard Gottingen Minipigs A/S
Researcher
Armoudjian, Yeghig
BioNotus GCV
Researcher
Van Daele, Johan
BioNotus GCV
Researcher
Annaert, Pieter
Katholieke Universiteit Leuven
Researcher
Huang, Miao-Chan
Katholieke Universiteit Leuven
Researcher
Macente, Julia
Katholieke Universiteit Leuven
Researcher
Anderson, Brian
Laboratory Corporation of America® Holdings
Researcher
Deposit date
20 Nov 2023 15:25
Last modified
20 Nov 2023 15:25
Project name
ConcePTION - Building an ecosystem for better monitoring and communicating of medication safety in pregnancy and breastfeeding: validated and regulatory endorsed workflows for fast, optimised evidence generation
Funding program
EC - H2020
URI

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