Abstract

This dataset contains molecular research data on the role of mitochondrial dysfunction in increasing vulnerability to cerebrovascular disorders in hypertension in stroke-prone spontaneously hypertensive rats (SHR-SP) fed with a high-salt stroke-permissive diet. When comparing SHR-SP strains to SHR-stroke resistant (SR) strains, the primary factor affecting the kinetic activity and SCs organisation of mitochondrial respiration is Complex I (CI) (dis)assembly in respiratory supercomplexes (SCs). In SHR-SP fed a high-salt diet, the arrangement of SCs and the leakage of substrate channelling in NADH oxidation CI-dependent were not observed under the same conditions in SHR-SR. Our findings demonstrate that the relationship of SCs with CI stability and dynamic protects against the manifestation of stroke.