Abstract

The dataset contains all the NMR spectra of the CF3 containing lactones and cyclic ethers synthetized with an electrochemical strategy. The protocol developed facilitates the synthesis of functionalized lactones and cyclic ethers from both terminal and internal alkenes exploiting the advantages of electrochemistry. Mechanistic insights, supported by cyclic voltammetry, radical trapping experiments, and DFT calculations, confirm the involvement of CF3 radicals. This metal-free protocol offers a sustainable and practical approach for accessing pharmacologically relevant scaffolds, underlining its potential for applications in medicinal chemistry.