Belvederi Murri, Martino ; Fanelli, Flaminia ; Pagotto, Uberto ; Bonora, Elena ; Triolo, Federico ; Chiri, Luigi ; Allegri, Fabio ; Mezzullo, Marco ; Menchetti, Marco ; Mondelli, Valeria ; Pariante, Carmine ; Berardi, Domenico ; Tarricone, Ilaria
(2016)
Neuroactive Steroids in First-Episode Psychosis:
A Role for Progesterone?
Schizophrenia Research and Treatment, 2016
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ISSN 2090-2093
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Official URL: https://www.hindawi.com/journals/schizort/2016/1942828/
Abstract
Neuroactive steroids may play a role in the pathophysiology of psychotic disorders, but few studies examined this issue. We compared serumlevels of cortisol, testosterone, dehydroepiandrosterone, and progesterone between a representative sample of firstepisode psychosis (FEP) patients and age- and gender-matched healthy subjects. Furthermore, we analyzed the associations between neuroactive steroids levels and the severity of psychotic symptom dimensions.Male patients had lower levels of progesterone than controls (
Abstract