Data related to “In Silico Clinical Trial for osteoporosis treatments to prevent hip fractures: simulation of the placebo arm”

Name: Data related to “In Silico Clinical Trial for osteoporosis treatments to prevent hip fractures: simulation of the placebo arm”
Keywords: Osteoporosis, Hip Fracture, Hip Protector, In Silico medicine, In Silico trial

Savelli, Giacomo (2024) Data related to “In Silico Clinical Trial for osteoporosis treatments to prevent hip fractures: simulation of the placebo arm”. University of Bologna. DOI 10.6092/unibo/amsacta/7934. [Dataset]

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Abstract

This dataset contains the characteristics of two synthetic cohorts of proximal femurs constructed via sampling a statistical anatomy atlas. These cohorts were used to simulate two In Silico Clinical Trial designed to replicate the placebo arm of as many concluded clinical trials described in literature (i.e. the LIFT study on teriparatide and FREEDOM study on Denosumab) to validate model’s ability to predict population-specific fracture incidence without treatment. Results in terms of fracture incidence are reported for each cohort.

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