Data related to “In Silico Clinical Trial for osteoporosis treatments to prevent hip fractures: simulation of the placebo arm”

Savelli, Giacomo (2024) Data related to “In Silico Clinical Trial for osteoporosis treatments to prevent hip fractures: simulation of the placebo arm”. University of Bologna. DOI 10.6092/unibo/amsacta/7934. [Dataset]
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Abstract

This dataset contains the characteristics of two synthetic cohorts of proximal femurs constructed via sampling a statistical anatomy atlas. These cohorts were used to simulate two In Silico Clinical Trial designed to replicate the placebo arm of as many concluded clinical trials described in literature (i.e. the LIFT study on teriparatide and FREEDOM study on Denosumab) to validate model’s ability to predict population-specific fracture incidence without treatment. Results in terms of fracture incidence are reported for each cohort.

Abstract
Document type
Dataset
Creators
CreatorsAffiliationORCID
Savelli, GiacomoDepartment of Industrial Engineering, Alma Mater Studiorum - University of Bologna (IT)0009-0004-7492-6436
Keywords
Osteoporosis, Hip Fracture, Hip Protector, In Silico medicine, In Silico trial
Subjects
Area 09 - Ingegneria industriale e dell'informazione > ING-IND/34 Bioingegneria industriale
DOI
10.6092/unibo/amsacta/7934
Contributors
Name
Affiliation
ORCID
Type
Oliviero, Sara
Department of Industrial Engineering, Alma Mater Studiorum - University of Bologna (IT)
Researcher
La Mattina, Antonino Amedeo
Medical Technology Lab, IRCCS Istituto Ortopedico Rizzoli, Bologna (IT)
Researcher
Viceconti, Marco
Department of Industrial Engineering, Alma Mater Studiorum - University of Bologna (IT)
Supervisor
Savelli, Giacomo
Department of Industrial Engineering, Alma Mater Studiorum - University of Bologna (IT)
Contact person
Deposit date
25 Oct 2024 08:37
Last modified
25 Oct 2024 08:37
Project name
ISW - In Silico World: Lowering barriers to ubiquitous adoption of In Silico Trials
Funding program
EC - H2020
URI
https://amsacta.unibo.it/id/eprint/7934

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