Data about the effect of short-chain PFAS exposure during gestation and breastfeeding on alteration of learning and memory in adulthood

Baldassarro, Vito Antonio (2025) Data about the effect of short-chain PFAS exposure during gestation and breastfeeding on alteration of learning and memory in adulthood. University of Bologna. DOI 10.6092/unibo/amsacta/8395. [Dataset]
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Abstract

The dataset includes detailed outcomes of in vivo and ex vivo tests, aimed to investigate the effect of short-chain Per- and polyfluoroalkyl substances (PFAS) maternal exposure on neurodevelopment in rats. Animals have been exposed to two different contaminants (PFBA, Perfluorobutanoic acid; and GenX, Ammonium Perfluoro, 2-methyl-3-oxahexanoate) at two different doses (indicated as LD, low dose, and HD, high dose) indirectly, through the maternal exposure (4 weeks pre-gestation, gestation, and lactation periods). Tests include a battery of standardized behavioral performed during adult life (9 weeks after weaning), assays designed to probe distinct facets of neurological function. Motor coordination and balance were quantitatively assessed via the Rotarod test. Spontaneous locomotion, reflecting exploratory behavior and anxiety-like states, was evaluated through open-field activity. Cognitive and mnemonic abilities were thoroughly investigated using the Morris water maze. In vivo analysis have been implemented with quantification of circulating hormones and gene expression data of neurogenesis marker in the hippocampus. Furthermore, the dataset integrates cell culture data from ex vivo studies, using primary hippocampl neurons (isolated from P0 pups exposed to PFBA during gestation) providing a comprehensive view. This dataset also includes quantitative analyses of short-chain PFAS residues in key tissues (liver, kidneys, brain, and thyroid).

Abstract
Tipologia del documento
Dataset
Autori
AutoreAffiliazioneORCID
Baldassarro, Vito AntonioDepartment of Veterinary Medical Sciences, University of Bologna, Bologna, Italy0000-0003-1020-4261
Parole chiave
PFAS, PFBA, GenX, short-chain PFAS, neurodevelopment
Settori scientifico-disciplinari
DOI
Contributors
Contributor
Affiliazione
ORCID
Tipo
Lorenzini, Luca
Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy
Researcher
Moretti, Marzia
Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy
Researcher
Zanardello, Claudia
Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro (Padova), Italy
Researcher
Gallocchio, Federica
Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro (Padova), Italy
Researcher
Baldassarro, Vito Antonio
Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy
Researcher
Moressa, Alessandra
Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro (Padova), Italy
Researcher
Zanella, Lorenzo
Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy
Researcher
Foiani, Greta
Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro (Padova), Italy
Researcher
Quadalti, Corinne
Department of Pharmacy and Biotcehnology, University of Bologna, Bologna, Italy
Researcher
Cescatti, Maura
IRET Foundation, Ozzano dell’Emilia, Bologna, Italy
Researcher
Burato, Valentina
IRET Foundation, Ozzano dell’Emilia, Bologna, Italy
Researcher
Soncin, Margherita
Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro (Padova), Italy
Researcher
Mancin, Marzia
Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro (Padova), Italy
Researcher
Giardino, Luciana
Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy
Researcher
Mutinelli, Franco
Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro (Padova), Italy
Researcher
Vascellari, Marta
Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro (Padova), Italy
Researcher
Calzà, Laura
Department of Pharmacy and Biotcehnology, University of Bologna, Bologna, Italy
Researcher
Baldassarro, Vito Antonio
Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy
Contact person
Data di deposito
24 Giu 2025 09:52
Ultima modifica
24 Giu 2025 09:52
URI

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