Abstract

This dataset characterizes a multifunctional, biodegradable bilayer wound dressing composed of a cross-linked polysaccharide-based multicomponent matrix that incorporates naturally derived bioactives, specifically sericin and Helix aspersa Müller secretion filtrate. Fabricated via solvent casting, the repository compiles comprehensive raw and processed data evaluating the material's physicochemical, mechanical, and morphological properties. Material characterization is documented through tensile testing, FT-IR, and UV–vis spectroscopy, while moisture management capabilities are quantified via swelling kinetics and water vapor transmission rate measurements. Furthermore, the dataset includes in vitro biological profiles consisting of safety evaluations via LDH and MTT cytotoxicity assays on HaCaT keratinocytes alongside functional efficacy data obtained through scratch wound healing assays. Collectively, these data files support the performance of a single-platform biomaterial that successfully integrates structural integrity and complete wound healing.