Dataset "PROEMA_REU": an Italian multicentric study about Leishmania infection in patients treated for immune-mediated inflammatory diseases with biologics.

Balducelli, Emma ; Torres, Ana ; Morselli, Sara ; Angheben, Andrea ; Piubelli, Chiara ; Perandin, Francesca ; Scarso, Salvatore ; Scambi, Cinzia ; Bartoloni, Alessandro ; Zammarchi, Lorenzo ; Barbiero, Anna ; Lagi, Filippo ; Spinicci, Michele ; Nacci, Francesca ; Ortalli, Margherita ; Baiocchi, Simone ; Bernardo, Lorena ; Moreno, Javier ; Carrillo, Eugenia ; Varani, Stefania (2025) Dataset "PROEMA_REU": an Italian multicentric study about Leishmania infection in patients treated for immune-mediated inflammatory diseases with biologics. Università di Bologna. DOI 10.6092/unibo/amsacta/8377. [Dataset]
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Abstract

The dataset includes information on 126 patients enrolled in an Italian study investigating asymptomatic Leishmania infection in individuals with immune-mediated inflammatory diseases undergoing treatment with biologic therapies. Leishmania infection was assessed using three diagnostic methods: (1) a Western Blot to detect specific IgG antibodies; (2) a semi-quantitative real-time PCR targeting kinetoplast (k)DNA minicircles; and (3) a Whole Blood Assay (WBA) measuring the levels of two cytokines, IL-2 and IP-10, using a Cytokine Bead Array (CBA) in plasma derived from blood samples stimulated with soluble Leishmania infantum antigens (SLA). Patients were considered positive if at least one of the three diagnostic tests yielded a positive result.

Abstract
Tipologia del documento
Dataset
Autori
AutoreAffiliazioneORCID
Balducelli, EmmaDepartment of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italyhttps://orcid.org/0009-0009-3154-5701
Torres, AnaWHO Collaborating Centre for Leishmaniasis, Spanish National Center for Microbiology, Instituto de Salud Carlos III, Majadahonda, Spainhttps://orcid.org/0000-0002-8968-2241
Morselli, SaraDepartment of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italyhttps://orcid.org/0000-0002-8400-0467
Angheben, AndreaDepartment of Infectious, Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, 37024 Negrar di Valpolicella, Verona, Italyhttps://orcid.org/0000-0003-4545-8034
Piubelli, ChiaraDepartment of Infectious, Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, 37024 Negrar di Valpolicella, Verona, Italyhttps://orcid.org/0000-0002-5739-3795
Perandin, FrancescaDepartment of Infectious, Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, 37024 Negrar di Valpolicella, Verona, Italyhttps://orcid.org/0000-0003-3933-3892
Scarso, SalvatoreDepartment of Infectious, Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, 37024 Negrar di Valpolicella, Verona, Italyhttps://orcid.org/0000-0003-2956-8997
Scambi, CinziaRheumatology Unit, Section of Rheumatology Department of Internal Medicine, IRCCS Sacro Cuore Don Calabria Hospital, 37024 Negrar di Valpolicella, Verona, Italyhttps://orcid.org/0000-0003-1353-379X
Bartoloni, AlessandroDepartment of Clinical and Experimental Medicine, Università degli Studi di Firenze, 50134 Firenze, Italy; Infectious and Tropical Diseases Unit, Azienda Ospedaliero Universitaria Careggi, 50134 Firenze, Italy;https://orcid.org/0000-0001-9758-1523
Zammarchi, LorenzoDepartment of Clinical and Experimental Medicine, Università degli Studi di Firenze, 50134 Firenze, Italy; Infectious and Tropical Diseases Unit, Azienda Ospedaliero Universitaria Careggi, 50134 Firenze, Italy;https://orcid.org/0000-0003-0892-8404);
Barbiero, AnnaDepartment of Clinical and Experimental Medicine, Università degli Studi di Firenze, 50134 Firenze, Italy; Infectious and Tropical Diseases Unit, Azienda Ospedaliero Universitaria Careggi, 50134 Firenze, Italyhttps://orcid.org/0009-0004-4152-9346
Lagi, FilippoInfectious and Tropical Diseases Unit, Azienda Ospedaliero Universitaria Careggi, 50134 Firenze, Italyhttps://orcid.org/0000-0003-0999-6070
Spinicci, MicheleDepartment of Clinical and Experimental Medicine, Università degli Studi di Firenze, 50134 Firenze, Italy; Infectious and Tropical Diseases Unit, Azienda Ospedaliero Universitaria Careggi, 50134 Firenze, Italyhttps://orcid.org/0000-0002-5377-7118
Nacci, FrancescaSection of Rheumatology, Department of Clinical and Experimental Medicine, Università degli Studi di Firenze, 50125 Florence, Italyhttps://orcid.org/0000-0002-2558-9785
Ortalli, MargheritaDepartment of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy; Unit of Microbiology, IRCSS Azienda Ospedaliero Universitaria di Bologna, 40138 Bologna, Italyhttps://orcid.org/0000-0001-5447-8817);
Baiocchi, SimoneUnit of Microbiology, IRCSS Azienda Ospedaliero Universitaria di Bologna, 40138 Bologna, Italy
Bernardo, LorenaWHO Collaborating Centre for Leishmaniasis, Spanish National Center for Microbiology, Instituto de Salud Carlos III, Majadahonda, Spainhttps://orcid.org/0000-0002-6899-4844
Moreno, JavierWHO Collaborating Centre for Leishmaniasis, Spanish National Center for Microbiology, Instituto de Salud Carlos III, Majadahonda, Spainhttps://orcid.org/0000-0003-0087-4659
Carrillo, EugeniaWHO Collaborating Centre for Leishmaniasis, Spanish National Center for Microbiology, Instituto de Salud Carlos III, Majadahonda, Spainhttps://orcid.org/0000-0002-7869-7915
Varani, StefaniaDepartment of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italyhttps://orcid.org/0000-0003-0862-4937
Parole chiave
Leishmania infection immune-mediated-inflammatory-diseases biologicalagents
Settori scientifico-disciplinari
Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
DOI
10.6092/unibo/amsacta/8377
Contributors
Contributor
Affiliazione
ORCID
Tipo
Varani, Stefania
Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy
Contact person
Data di deposito
06 Giu 2025 08:15
Ultima modifica
06 Giu 2025 08:17
Nome del Progetto
PROEMA_2018 - Emerging blood protozoa in the immunocompromised population: novel strategies for screening, diagnosis, monitoring and clinical management
Programma di finanziamento
Ministero della salute (Italy); Instituto de Salud Carlos III (Madrid, Spain) - grant number RF-2016-02361931; ISCIII-AES project; n. PI22/00009
URI
https://amsacta.unibo.it/id/eprint/8377

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