Dataset "PROEMA_REU": an Italian multicentric study about Leishmania infection in patients treated for immune-mediated inflammatory diseases with biologics.

Balducelli, Emma ; Torres, Ana ; Morselli, Sara ; Angheben, Andrea ; Piubelli, Chiara ; Perandin, Francesca ; Scarso, Salvatore ; Scambi, Cinzia ; Bartoloni, Alessandro ; Zammarchi, Lorenzo ; Barbiero, Anna ; Lagi, Filippo ; Spinicci, Michele ; Nacci, Francesca ; Ortalli, Margherita ; Baiocchi, Simone ; Bernardo, Lorena ; Moreno, Javier ; Carrillo, Eugenia ; Varani, Stefania (2025) Dataset "PROEMA_REU": an Italian multicentric study about Leishmania infection in patients treated for immune-mediated inflammatory diseases with biologics. Università di Bologna. DOI 10.6092/unibo/amsacta/8377. [Dataset]
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Abstract

The dataset includes information on 126 patients enrolled in an Italian study investigating asymptomatic Leishmania infection in individuals with immune-mediated inflammatory diseases undergoing treatment with biologic therapies. Leishmania infection was assessed using three diagnostic methods: (1) a Western Blot to detect specific IgG antibodies; (2) a semi-quantitative real-time PCR targeting kinetoplast (k)DNA minicircles; and (3) a Whole Blood Assay (WBA) measuring the levels of two cytokines, IL-2 and IP-10, using a Cytokine Bead Array (CBA) in plasma derived from blood samples stimulated with soluble Leishmania infantum antigens (SLA). Patients were considered positive if at least one of the three diagnostic tests yielded a positive result.

Abstract
Tipologia del documento
Dataset
Autori
AutoreORCIDAffiliazioneROR
Balducelli, Emmahttps://orcid.org/0009-0009-3154-5701Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy
Torres, Anahttps://orcid.org/0000-0002-8968-2241WHO Collaborating Centre for Leishmaniasis, Spanish National Center for Microbiology, Instituto de Salud Carlos III, Majadahonda, Spain
Morselli, Sarahttps://orcid.org/0000-0002-8400-0467Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy
Angheben, Andreahttps://orcid.org/0000-0003-4545-8034Department of Infectious, Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, 37024 Negrar di Valpolicella, Verona, Italy
Piubelli, Chiarahttps://orcid.org/0000-0002-5739-3795Department of Infectious, Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, 37024 Negrar di Valpolicella, Verona, Italy
Perandin, Francescahttps://orcid.org/0000-0003-3933-3892Department of Infectious, Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, 37024 Negrar di Valpolicella, Verona, Italy
Scarso, Salvatorehttps://orcid.org/0000-0003-2956-8997Department of Infectious, Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, 37024 Negrar di Valpolicella, Verona, Italy
Scambi, Cinziahttps://orcid.org/0000-0003-1353-379XRheumatology Unit, Section of Rheumatology Department of Internal Medicine, IRCCS Sacro Cuore Don Calabria Hospital, 37024 Negrar di Valpolicella, Verona, Italy
Bartoloni, Alessandrohttps://orcid.org/0000-0001-9758-1523Department of Clinical and Experimental Medicine, Università degli Studi di Firenze, 50134 Firenze, Italy; Infectious and Tropical Diseases Unit, Azienda Ospedaliero Universitaria Careggi, 50134 Firenze, Italy;
Zammarchi, Lorenzohttps://orcid.org/0000-0003-0892-8404);Department of Clinical and Experimental Medicine, Università degli Studi di Firenze, 50134 Firenze, Italy; Infectious and Tropical Diseases Unit, Azienda Ospedaliero Universitaria Careggi, 50134 Firenze, Italy;
Barbiero, Annahttps://orcid.org/0009-0004-4152-9346Department of Clinical and Experimental Medicine, Università degli Studi di Firenze, 50134 Firenze, Italy; Infectious and Tropical Diseases Unit, Azienda Ospedaliero Universitaria Careggi, 50134 Firenze, Italy
Lagi, Filippohttps://orcid.org/0000-0003-0999-6070Infectious and Tropical Diseases Unit, Azienda Ospedaliero Universitaria Careggi, 50134 Firenze, Italy
Spinicci, Michelehttps://orcid.org/0000-0002-5377-7118Department of Clinical and Experimental Medicine, Università degli Studi di Firenze, 50134 Firenze, Italy; Infectious and Tropical Diseases Unit, Azienda Ospedaliero Universitaria Careggi, 50134 Firenze, Italy
Nacci, Francescahttps://orcid.org/0000-0002-2558-9785Section of Rheumatology, Department of Clinical and Experimental Medicine, Università degli Studi di Firenze, 50125 Florence, Italy
Ortalli, Margheritahttps://orcid.org/0000-0001-5447-8817);Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy; Unit of Microbiology, IRCSS Azienda Ospedaliero Universitaria di Bologna, 40138 Bologna, Italy
Baiocchi, SimoneUnit of Microbiology, IRCSS Azienda Ospedaliero Universitaria di Bologna, 40138 Bologna, Italy
Bernardo, Lorenahttps://orcid.org/0000-0002-6899-4844WHO Collaborating Centre for Leishmaniasis, Spanish National Center for Microbiology, Instituto de Salud Carlos III, Majadahonda, Spain
Moreno, Javierhttps://orcid.org/0000-0003-0087-4659WHO Collaborating Centre for Leishmaniasis, Spanish National Center for Microbiology, Instituto de Salud Carlos III, Majadahonda, Spain
Carrillo, Eugeniahttps://orcid.org/0000-0002-7869-7915WHO Collaborating Centre for Leishmaniasis, Spanish National Center for Microbiology, Instituto de Salud Carlos III, Majadahonda, Spain
Varani, Stefaniahttps://orcid.org/0000-0003-0862-4937Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy
Parole chiave
Leishmania infection immune-mediated-inflammatory-diseases biologicalagents
Settori scientifico-disciplinari
Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
DOI
10.6092/unibo/amsacta/8377
Contributors
Contributor
ORCID
Tipo
Affiliazione
Varani, Stefania
Contact person
Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy
Data di deposito
06 Giu 2025 08:15
Ultima modifica
06 Giu 2025 08:17
Nome del Progetto
PROEMA_2018 - Emerging blood protozoa in the immunocompromised population: novel strategies for screening, diagnosis, monitoring and clinical management
Programma di finanziamento
Ministero della salute (Italy); Instituto de Salud Carlos III (Madrid, Spain) - grant number RF-2016-02361931; ISCIII-AES project; n. PI22/00009
URI
https://amsacta.unibo.it/id/eprint/8377

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