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Fantoni, Tommaso ; Rizzo, Silvia ; Reusser, Esaïe ; Tolomelli, Alessandra ; Albrecht, Martin ; Cabri, Walter
(2025)
A New Class of Bidentate Nitrogen Ligands for Suzuki–Miyaura Cross-Coupling of Aryl Iodides and Bromides in Green Solvents.
University of Bologna.
DOI 10.6092/unibo/amsacta/8564.
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Abstract
Inexpensive nitrogen-based bidentate pyridinium amidate ligands with simple Pd(II) salts generate in situ Pd(0) catalysts that efficiently promote Suzuki–Miyaura cross-coupling of aryl iodides and bromides. Operating at very low palladium loadings (0.1–0.005 mol%) with TONs up to 17800, the reactions give high yields (51–96%) using K2CO3 in a green hydroxyethyl pyrrolidone/water (6:4) solvent mixture. The protocol minimizes metal residues, allows >90% palladium recovery and reduces PMI from 30 to 8. DFT studies indicate transmetalation as the rate-determining step.
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