Raw Data on Propranolol in Pig Plasma

Name: Raw Data on Propranolol in Pig Plasma
Keywords: Beta-blocker; oral administration; blood concentrations; 4-hydroxypropranolol; swine; pharmacokinetics; micro sampling.

Bardhi, Anisa ; Ventrella, Domenico ; Elmi, Alberto ; Gehring, Ronette ; Martelli, Davide ; Troisio, Ilaria ; Bacci, Maria Laura ; Barbarossa, Andrea (2025) Raw Data on Propranolol in Pig Plasma. University of Bologna. DOI 10.6092/unibo/amsacta/8573. [Dataset]

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Abstract

This dataset supports a study on the pharmacokinetics of propranolol in pig plasma. The study focused on the development and validation of a rapid and sensitive LC-MS/MS method for the simultaneous quantification of propranolol and its metabolite, 4-hydroxypropranolol, in pig plasma and dried blood spots (DBS). The method demonstrated excellent linearity, accuracy, and precision, and its application to a pharmacokinetic study in pigs revealed the absence of 4-hydroxypropranolol, providing new insights into propranolol metabolism in this species.

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Autori

Autore	ORCID	Affiliazione
Bardhi, Anisa	0000-0002-2012-2852	Department of Veterinary Medical Science, University of Bologna
Ventrella, Domenico	0000-0002-9330-979X	Department of Veterinary Medical Science, University of Bologna
Elmi, Alberto	0000-0002-7827-5034	Department of Veterinary Science, University of Pisa
Gehring, Ronette	0000-0002-1329-201X	Department of Population Health Sciences, Institute for Risk Assessment Sciences (IRAS), Faculty of Veterinary Medicine, Utrecht University
Martelli, Davide	0000-0001-6523-9598	Department of Biomedical and Neuromotor Sciences, University of Bologna
Troisio, Ilaria	0000-0002-8092-2093	Department of Veterinary Medical Science, University of Bologna
Bacci, Maria Laura	0000-0001-6702-5868	Department of Veterinary Medical Science, University of Bologna
Barbarossa, Andrea	0000-0002-7742-4229	Department of Veterinary Medical Science, University of Bologna