Raw Data on Propranolol in Pig Plasma

Bardhi, Anisa ; Ventrella, Domenico ; Elmi, Alberto ; Gehring, Ronette ; Martelli, Davide ; Troisio, Ilaria ; Bacci, Maria Laura ; Barbarossa, Andrea (2025) Raw Data on Propranolol in Pig Plasma. University of Bologna. DOI 10.6092/unibo/amsacta/8573. [Dataset]
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Abstract

This dataset supports a study on the pharmacokinetics of propranolol in pig plasma. The study focused on the development and validation of a rapid and sensitive LC-MS/MS method for the simultaneous quantification of propranolol and its metabolite, 4-hydroxypropranolol, in pig plasma and dried blood spots (DBS). The method demonstrated excellent linearity, accuracy, and precision, and its application to a pharmacokinetic study in pigs revealed the absence of 4-hydroxypropranolol, providing new insights into propranolol metabolism in this species.

Abstract
Document type
Dataset
Creators
CreatorsAffiliationORCID
Bardhi, AnisaDepartment of Veterinary Medical Science, University of Bologna0000-0002-2012-2852
Ventrella, DomenicoDepartment of Veterinary Medical Science, University of Bologna0000-0002-9330-979X
Elmi, AlbertoDepartment of Veterinary Science, University of Pisa0000-0002-7827-5034
Gehring, RonetteDepartment of Population Health Sciences, Institute for Risk Assessment Sciences (IRAS), Faculty of Veterinary Medicine, Utrecht University0000-0002-1329-201X
Martelli, DavideDepartment of Biomedical and Neuromotor Sciences, University of Bologna0000-0001-6523-9598
Troisio, IlariaDepartment of Veterinary Medical Science, University of Bologna0000-0002-8092-2093
Bacci, Maria LauraDepartment of Veterinary Medical Science, University of Bologna0000-0001-6702-5868
Barbarossa, AndreaDepartment of Veterinary Medical Science, University of Bologna0000-0002-7742-4229
Keywords
Beta-blocker; oral administration; blood concentrations; 4-hydroxypropranolol; swine; pharmacokinetics; micro sampling.
Subjects
Area 07 - Scienze agrarie e veterinarie > VET/02 Fisiologia veterinaria
Area 07 - Scienze agrarie e veterinarie > VET/07 Farmacologia e tossicologia veterinaria
DOI
10.6092/unibo/amsacta/8573
Contributors
Name
Affiliation
ORCID
Type
Barbarossa, Andrea
Department of Veterinary Medical Science, University of Bologna
Contact person
Deposit date
21 Oct 2025 12:49
Last modified
21 Oct 2025 12:49
URI
https://amsacta.unibo.it/id/eprint/8573

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© ALMA MATER STUDIORUM - Università di Bologna, 2007-2025.

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